Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC50 = 40 μM). It has an antiapoptotic effect, inhibiting bile acid-induced hepatocellular apoptosis by maintaining mitochondrial membrane potential.
| Synonyms | TβMCA |
|---|---|
| Formula | C26H45NO7S |
| Molecular Weight | 515.70 |
| SMILES | C[C@@]12[C@]3([H])[C@]([C@H]([C@H]([C@]1([H])C[C@@H](CC2)O)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)C |
| Biological Target | FXR; Apoptosis |
| Target | 40 μM (FXR) |
| Initial Source | Endogenous metabolite; Human Gut Microbiota Metabolites; Animals; Microorganisms; rat |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |
Datasheet