It potently activates mitochondrial caseinolytic protease P (ClpP), leading to eIF2α-independent induction of ATF4 and Akt/ERK/Foxo3a/DR5/TRAIL-dependent apoptosis.
| Formal Name | 7-Benzyl-4-(2-methylbenzyl)-1, 2, 6, 7, 8, 9-hexahydroimidazo[1, 2-a]pyrido[3, 4-e]pyrimidin-5(4H)-one |
|---|---|
| Synonyms | ONC201 |
| Purity | >98% |
| CAS Number | 1616632-77-9 |
| Formula | C24H26N4O |
| Molecular Weight | 386.49 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 25 mg/mL with warming) |
| Stability | ≥ 1 year |
| Application Procedures | First, dissolve in DMSO (up to 25 mg/mL with warming), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20° for up to 2 months. |
| Storage Information | -20°C |
Mitochondrial caseinolytic protease P activator / Anticancer agent
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