Piperlongumine

Cat. No. IC23140

CAS. No. 20069-09-4

Key Features and Details

Category

Inhibitor&Activator

Purity

98.23%

Formula

C17H19NO5

Product Size

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Product Details

Product Name

Piperlongumine

CAS No.

20069-09-4

Molecular Weight

317.34

Synonyms

Piplartine

Formula

C17H19NO5

Appearance

Solid

Purity

98.23%

SMILES

O=C1C=CCCN1C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O

Product Overview

Description

Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome.

In Vitro Activity

Piplartine (5, 10, and 15 μM) significantly decreases cell proliferation of 786-O, SKBR3, Panc1, A549, and L3.6pL cancer cells after treatment for 24 and 48 hours, induces apoptosis and ROS in these cell lines at 5 and 10 μM after 3 or 9 h of treatment. Piplartine (5 or 10 μM) induces cleaved PARP and downregulates Sp1, Sp3, Sp4, and Sp-regulated genes. Piplartine (20 μM) decreases the viability of cardiac fibroblasts (CFs). Piplartine (0-10 μM) suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway.

In Vivo Activity

Piperlongumine exhibits potent anti-tumor effect in athymic nude mice bearing L3.6pL cells without body weight loss.

Storage & Handling

Storage

Powder, -20 °C, 3 years; 4 °C, 2 years In solvent: -80 °C, 6 months, -20 °C, 1 month.

Shipping

Room temperature in continental US; may vary elsewhere.

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