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Bardoxolone Methyl
Cat. No. IC23034
CAS. No. 218600-53-4
Key Features and Details
Category
Inhibitor&Activator
Purity
98.47%
Formula
C32H43NO4
Product Details
Product Name
Bardoxolone Methyl
CAS No.
218600-53-4
Molecular Weight
505.69
Target
Nrf2
Synonyms
RTA 402; NSC 713200; CDDO Methyl ester
Formula
C32H43NO4
Appearance
Solid
Purity
98.47%
SMILES
O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@@]5([H])[C@@](CCC(C)(C)C5)(C(OC)=O)CC3)(C)C2=CC4=O)([H])C1(C)C
Product Overview
Description
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
In Vivo Activity
Bardoxolone methyl decreases renal expression of megalin but not cubilin, increases creatinine clearance and urinary albumin-to-creatinine ratios, and induces Nrf2 cytoprotective targets in cynomolgus monkeys. Bardoxolone methyl induces overall favorable effects on the heart via its improvement in eGFR in both animal models and clinical trials.
Storage & Handling
Storage
Powder, -20 °C, 3 years; 4 °C, 2 years
In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
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