Acetylcysteine

Cat. No. IC23024

CAS. No. 616-91-1

Key Features and Details

Category

Inhibitor&Activator

Purity

≥98.0%

Formula

C5H9NO3S

Product Size

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Product Details

Product Name

Acetylcysteine

CAS No.

616-91-1

Molecular Weight

163.19

Target

Human Endogenous Metabolite

Synonyms

N-Acetylcysteine; N-Acetyl-L-cysteine; NAC

Formula

C5H9NO3S

Appearance

Solid

Purity

≥98.0%

SMILES

SC[C@@H](C(O)=O)NC(C)=O

Product Overview

Description

Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities.

In Vitro Activity

Acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. Acetylcysteine also prevents death of PC12 cells and sympathetic neurons.Acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. Acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. Acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. Acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. Acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it is suggested that Acetylcysteine interferes with redox-sensitive steps in the NGF mechanism.

In Vivo Activity

Acetylcysteine (150, 300 mg/kg) treatment significantly reduces liver transaminases in all groups of treatment, mostly in group Acetylcysteine 300. Lung glutathione peroxidase is significantly increases in group Acetylcysteine 300 (P=0.04), while the other oxidation biomarkers show no significant differences[6].Acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight.

Storage & Handling

Storage

4 °C, protect from light In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light)

Shipping

Room temperature in continental US; may vary elsewhere.

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