Lovastatin

Cat. No. IC23126

CAS. No. 75330-75-5

Key Features and Details

Category

Inhibitor&Activator

Purity

99.68%

Formula

C24H36O5

Product Size

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Product Details

Product Name

Lovastatin

CAS No.

75330-75-5

Molecular Weight

404.54

Synonyms

Mevinolin

Formula

C24H36O5

Appearance

Solid

Purity

99.68%

SMILES

O=C([C@@H](C)CC)O[C@@H]1[C@@]([C@H]2CC[C@@H](OC3=O)C[C@H](C3)O)([H])C(C=C[C@@H]2C)=C[C@H](C)C1

Product Overview

Description

Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

In Vitro Activity

Lovastatin (10 μM; 72 hours) efficiently reduces viability of HepG2 cells. Lovastatin (10 μM; 48 hours) induces apoptosis in HepG2 cells.

In Vivo Activity

Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol.

Storage & Handling

Storage

Powder, -20 °C, 3 years; 4 °C, 2 years In solvent: -80 °C, 6 months, -20 °C, 1 month.

Shipping

Room temperature in continental US; may vary elsewhere.

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