Antigen Identification: The development of a vaccine pivots on the existence of any specific antigens that may trigger a protective immune response in human beings. Researchers have identified proteins produced from the Secreted Ancylostoma larvae which have the potential to enhance immune evasion. For formulation of subunit vaccines that might provide protection against CLM, research on immunogenic aspects of these proteins must be conducted.
DNA Vaccines: One of the modern strategies for combating CLM is DNA vaccination. Plasmids containing specific Ancylostoma antigens are expected to initiate a strong immune response among the target individuals. This technique has been proven effective against other parasitic infections, like Metastrongylias, and may be tailored to work on CLM. For instance, within the species of animals, preliminary research have confirmed that DNA vaccines are protective, and therefore, human trials can be pursued.