Development of a vaccine for PML is a difficult task because of the JC virus and the targeted demographic. The research in development of JCV specific vaccines targets the ability of the immune system to detect ns offset JCV and neutralize it before it spreads. This includes the creation of sub-unit vaccines to control JCV, modular viruses or other JCV elements like protein that induce immune response which helps neutralize JCV.
Another directions worth pursuing involves the creation of viral vectors cages with JCV specific antigens. These viruses are usually made from live, but weakened, or dead viruses. These vectors can put JCV DNA in the host's cells; after which, the cell makes JCV proteins, for the immune system to recognize them. This technique has been suggested in preclinical tests; however, preclinical use has shown great trouble making and proving the safety and effectiveness of vaccines.