Cisplatin

Cat. No. IC23116

CAS. No. 15663-27-1

Key Features and Details

Category

Inhibitor&Activator

Formula

Cl2H6N2Pt

Product Size

Online Inquiry

Product Details

Product Name

Cisplatin

CAS No.

15663-27-1

Molecular Weight

300.05

Synonyms

cis-Platinum; CDDP; cis-Diaminodichloroplatinum

Formula

Cl2H6N2Pt

Appearance

Solid

SMILES

Cl[Pt](Cl)([NH3])[NH3]

Product Overview

Description

Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy.

In Vitro Activity

Cisplatin (CDDP) causes apoptosis of HeLa cells in a dose-dependent manner, with a concentration of 30 μM Cisplatin resulting in death of greater than 90% of the cell population by 24 h of treatment. The kinetics of Cisplatin-induced apoptosis are examined using a 30 μM concentration. Cisplatin Activates the MEK/ERK Signaling Pathway, 20 and 30 μM Cisplatin, both of which results in significant apoptosis, leads to strong activation of ERK. Cisplatin (50 μM) produces time-dependent apoptosis in renal proximal tubular cell (RPTCs), causing cell shrinkage, a 50-fold increase in caspase 3 activity, a 4-fold increase in phosphatidylserine externalization, and 5- and 15-fold increases in chromatin condensation and DNA hypoploidy, respectively.

In Vivo Activity

In melanoma-bearing mice, Cisplatin (CDDP; 4 mg/kg B.W.) reduces the size and weight of the solid tumors, and HemoHIM supplementation with Cisplatin enhances the decrease of both the tumor size and weight. Cisplatin administration results in significant increases in the kidney weight as a percentage of the total body weight, urine volume, serum creatinine, and blood urea nitrogen by about 132, 315, 797, and 556% in comparison with the control rats, respectively.

Storage & Handling

Storage

4 °C, protect from light In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light)

Shipping

Room temperature in continental US; may vary elsewhere.

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