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Microtubule Inhibitor 2
Cat. No. IC23220
CAS. No.
Product Details
Product Name
Microtubule Inhibitor 2
Molecular Weight
389.4
Formula
C20H23NO7
SMILES
C=C(C1=CC=C(C(O)=C1NC(CO)=O)OC)C2=CC(OC)=C(C(OC)=C2)OC
Product Overview
Description
Microtubule inhibitor 2 is a potent and selective, orally active microtubule inhibitor. Microtubule inhibitor 2 triggers cell death through ferroptosis . Microtubule inhibitor 2 shows antitumor activity.
In Vitro Activity
Microtubule inhibitor 2 (compound 33) (48 h) shows antiproliferative activity with IC50 values of 0.01, 0.02, 0.02, 0.04, 0.05 µM for A549, Hela, A2780, HCT-8, MCF-7 cells, respectively.
Microtubule inhibitor 2 shows selective toward normal human cells and cancer cells (IC50s of 0.01, 0.04, 1.45, 1.32,0.54 µM for A549, quiescent HUVECs, LO2, HLF, MCF-10A cells, respectively).
Microtubule inhibitor 2 (48 h) shows antiproliferative activity toward drug-resistant cancer cells (IC50s of 0.02, 0.07, 0.04 for A549/ADM, HCT-8/VCR, A2780/TAX cells, respectively).
Microtubule inhibitor 2 (5, 10, 20 nM, 24 h, 48 h) arrests cell cycle progression at the G2/M phase in a dose and time-dependent manner.
Microtubule inhibitor 2 triggers cell death through ferroptosis rather than apoptosis.
In Vivo Activity
Microtubule inhibitor 2 (10 mg/kg; p.o.)displays excellent oral bioavailability (F% = 69.45) .
Microtubule inhibitor 2 (10 mg/kg; i.p.; every other day for 22 days) shows antitumor activity and the level of tumor growth inhibition was 78.63%.
Storage & Handling
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
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