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Vildagliptin Dihydrate
Cat. No. IC23074
CAS. No. 2133364-01-7
Key Features and Details
Category
Inhibitor&Activator
Formula
C17H29N3O4
Product Details
Product Name
Vildagliptin Dihydrate
CAS No.
2133364-01-7
Molecular Weight
339.43
Target
DPP-IV, In Human Caco-2 cells
Synonyms
LAF237 dihydrate; NVP-LAF 237 dihydrate
Formula
C17H29N3O4
IC50/EC50
IC50: 3.5 nM (DPP-IV, in human Caco-2 cells)
SMILES
O[C@@]1(C[C@H](C2)C3)C[C@H]3C[C@@]2(NCC(N4CCC[C@H]4C#N)=O)C1.O.O
Product Overview
Description
Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity.
In Vitro Activity
Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation.
In Vivo Activity
Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice.
Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats.
Storage & Handling
Storage
Powder, -20 °C, 3 years; 4 °C, 2 years
In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
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