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Vildagliptin
Cat. No. IC23050
CAS. No. 274901-16-5
Key Features and Details
Category
Inhibitor&Activator
Purity
98.18%
Formula
C17H25N3O2
Product Details
Product Name
Vildagliptin
CAS No.
274901-16-5
Molecular Weight
303.40
Target
DPP-IV, In Human Caco-2 Cells
Synonyms
LAF237; NVP-LAF 237
Formula
C17H25N3O2
Appearance
Solid
Purity
98.18%
IC50/EC50
IC50: 3.5 nM
SMILES
O[C@@]1(C2)C[C@H]3C[C@H](C[C@]2(NCC(N4[C@H](C#N)CCC4)=O)C3)C1
Product Overview
Description
Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.
In Vitro Activity
Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation.
In Vivo Activity
Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice.
Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats.
Storage & Handling
Storage
Powder, -20 °C, 3 years; 4 °C, 2 years
In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
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