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Rosiglitazone-d3
Cat. No. IC23112
CAS. No. 1132641-22-5
Key Features and Details
Category
Inhibitor&Activator
Formula
C18H16D3N3O3S
Product Details
Product Name
Rosiglitazone-d3
CAS No.
1132641-22-5
Molecular Weight
360.45
Formula
C18H16D3N3O3S
SMILES
O=C(N1)C(CC2=CC=C(OCCN(C3=NC=CC=C3)C([2H])([2H])[2H])C=C2)SC1=O
Product Overview
Description
Rosiglitazone-d3 (BRL 49653-d3) is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone binds to PPARγ with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC50=30 μM) and an inhibitor of TRPM3.
In Vitro Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Storage & Handling
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
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