Cell-based Model Development Service

Models that are built around cells are relevant for developing therapeutics for ophthalmic diseases as they offer a link between drug discovery and preclinical work. Protheragen focuses on the creation of sophisticated cell-based models custom-designed for specific requirements in ophthalmic research and therapeutics.

Introduction to Cell-based Models

Cell-based models function like living laboratories that provide scientists with the opportunity to understand the behaviour of cells under various conditions. Picture watching the finer details of a cell's activity, including how cells interact with one another and their reactions to different stimuli. These models are formed through growing cells in a controlled environment such as in dishes or on specific scaffolds which enable researchers to recreate the human body. They serve as remarkable mitigation devices in assisting researchers to comprehend the most rudimentary processes of life such as the division and growth of cells, as well as their responses to disease and therapeutic scenarios.

Fig.1 Cell types and different states. (Zeng H., 2022)

Application of Cell Models in Ophthalmic Diseases

Due to the complex structure and specialized features of the human eye, drug delivery, and disease modeling purposes remain extraordinarily challenging. Cell models enable scientists to perform reproducible, controlled studies on the effects of drugs on certain eye tissues, including the cornea, retina, and retinal pigment epithelium. These models allow researchers to investigate the processes underlying ocular diseases, test new drugs, and assess the safety and effectiveness of medications. To overcome the divide between in vitro and in vivo approaches, cell models provide reasonable replicas of the ocular environment which, as a result, enable the faster creation of new therapies to treat eye diseases.

Table 1. Cell culture models of blood-brain barriers. (Shafaie S., et al., 2016)

Our Services

Our services at Protheragen are customized to ensure that researchers and pharmaceutical companies create novel therapies for ocular diseases. From custom cell model development to model validation and optimization, we offer a full suite of services. An expert is assigned to every client to make certain that every model is tailored to their research's data needs.

Other Optional Cell Models

• RPE-19
• ARPE-19
• ARPE-19mel
• LEPI
• hfRPE

• hESC-RPE
• HCE-T
• OCM1
• MUM2C
• OCM3

• OCM8
• MUM2B
• M619
• C918
• BOEC

At Protheragen, we are committed to advancing the field of ophthalmic research through the development of innovative cell-based models. If you are interested in our services, please feel free to contact us.

References

• Zeng, Hongkui. "What is a cell type and how to define it?." Cell 185.15 (2022): 2739-2755.
• Kutlehria, Shallu, and Mandip Sachdeva Singh. "Role of in vitro models for development of ophthalmic delivery systems." Critical Reviews™ in Therapeutic Drug Carrier Systems 38.3 (2021).
• Shafaie, Sara, et al. "In vitro cell models for ophthalmic drug development applications." BioResearch open access 5.1 (2016): 94-108.