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Developing efficient therapies for eye diseases greatly depends on preclinical studies performed on animal models that closely resemble humans. Here at Protheragen, we utilize our vast knowledge of biology and preclinical research to provide full-scope surgical animal model development services aimed at the production of ophthalmic disease therapeutics.
Surgical animal models are crucial for our search since they enable scientists to analyze the causation of diseases, determine the validity and safety of new procedures, and lay the groundwork for clinical practice. These models include surgical manipulations of the animals to produce certain eye diseases resembling important aspects of human eye disorders. The controlled onset and advancement of the diseases enables researchers to obtain a deep understanding of the disease and its therapeutic possibilities.
Fig.1 Sheep biomedical models for human physiology and diseases. (Banstola A., et al., 2022)
Retinal Diseases
Surgical animal models are crucial for the understanding of retinal diseases like age-related macular degeneration (AMD) and diabetic retinopathy. These models assist with the investigation of surgical and therapeutic interventions with retinal function and structure. For instance, laser-induced choroidal neovascularization (CNV) models in rodents and primates are routinely used to understand the pathogenesis of AMD and evaluate anti-angiogenic therapeutics.
Corneal Diseases
To gain insight into the genetic and environmental causes of corneal diseases uch as corneal dystrophies and keratoconus, animal models are surgically prepared. New therapeutics approaches and surgical procedures are tested by employing methods such as corneal transplantation and induced corneal injury. For example, models of alkali burns in rabbits and mice aid in studying the processes of corneal neovascularization and in the testing of therapies aimed at inhibiting blood vessel growth.
Glaucoma
The pathophysiological progression of glaucoma involves a cascade of events that ultimately lead to optic nerve damage and visual field loss. This intricate process can be effectively investigated and better understood through the use of specialized models such as laser-induced ocular hypertension. These models provide a controlled and reproducible environment to simulate the conditions of elevated intraocular pressure (IOP) that are characteristic of glaucoma.
For the creation of surgical animal models customized for the advancement of ophthalmic therapeutics, Protheragen provides multifaceted services. We craft, execute, and assess the surgical animal models and guarantee that each one is tailored for the therapeutic development of ophthalmic disorders at the highest level.
Intraocular Pressure Elevation Models
These models require surgical intervention to artificially raise the intrabulbar pressure simulating glaucoma. Methods include laser damage to the trabecular meshwork and viscoelastic or microbead injections into the anterior chamber.
Lens Injury Models
Induction of cataracts is achievable through surgical processes designed to osseously opacity the lenses. This may include directly puncturing, or using caustic chemicals to damage, the lens capsule and/or fibrous tissues.
Retinal Detachment Models
The models are created by surgically separating the neurosensory retina from the retinal pigment epithelium through, in many cases, subretinal fluid or viscoelastic material injection.
Corneal Injury and Neovascularization Models
Surgical abrasion, suture placement on the eye's cornea, or even superficial chemical burns may lead to corneal injury and neovascularization, simulating many kinds of corneal diseases.
Lacrimal System Manipulation Models
Surgical closure or removal of lacrimal glands or ducts can be done to create conditions similar to dry eyes.
Custom Surgical Model Development
We can develop novel surgical techniques or modify existing ones to create highly specific disease models.
At Protheragen, our commitment is to provide our clients with the highest quality surgical animal models and preclinical research services to accelerate the development of innovative therapies for ophthalmic diseases. If you are interested in our services, please feel free to contact us.
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