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- Iridogoniodysgenesis (Dominant Type)
Iridogoniodysgenesis (Dominant Type, type 1, IRID1) is a complex genetic disorder with significant implications for vision and overall quality of life. As a research service provider, Protheragen is at the forefront of diagnostics and therapeutics development for Iridogoniodysgenesis.
Iridogoniodysgenesis is a group of inherited eye disorders characterized by abnormalities in the development of the iris and the iridocorneal angle tissue, leading to goniodysgenesis and increased intraocular pressure, which can result in juvenile glaucoma. The dominant type of IRID1 is inherited in an autosomal dominant pattern, with genetic mutations playing a crucial role in its pathogenesis.
The genetic basis of IRID1 has been a significant area of research, leading to the discovery of mutations in the RIEG1 gene on chromosome 4q25. This gene encodes a homeobox protein, which is a transcription factor involved in the development of the anterior segment of the eye. Mutations in RIEG1 result in the production of an aberrant protein, leading to the characteristic ocular abnormalities seen in IRID1.
Genetic Diagnostics
The advent of genetic testing has revolutionized the diagnostics of IRID1. Identification of specific mutations in the RIEG1 gene allows for a definitive diagnosis. This genetic information is crucial for understanding the disease's inheritance patterns and for providing genetic counseling to families.
As a research services provider, Protheragen offers customized iridogoniodysgenesis diagnostics and therapeutic development solutions based on the unique needs of each project. Our team of experts works closely with clients to understand their specific needs and develop targeted therapeutic development strategies.
Our preclinical research services are tailored to explore and elucidate the underlying mechanisms of IGDS, offering a platform for the development of innovative therapeutic strategies. Protheragen's dedicated team of scientists employs cutting-edge technologies and methodologies to conduct comprehensive analyses, including:
If you are interested in our services, please feel free to contact us.
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