Coarctation of the Aorta

Coarctation of the aorta is a type of congenital cardiovascular defect and represents almost 6-8% of congenital heart disease. Coarctation of the aorta is defined as the narrowing of the aorta and has been considered a part of multifocal arteriopathy, frequently situated at the insertion of the ductus arteriosus, and affects the aortic arch or isthmus. At Protheragen, we provide comprehensive preclinical research services to expedite advancements in rare cardiovascular conditions, such as coarctation of the aorta.

Introduction to Coarctation of the Aorta

Coarctation of the aorta is considered one of the most critical birth defects of the aorta, with varied incidence figures between 3 to 4 cases of aortic defects per 10,000 newborns, along with a male-to-female ratio of 2:1. Coarctation of the aorta might manifest as a solitary defect but can also be linked to several additional congenital disorders. The presentation of coarctation of the aorta is determined by the severity of the lesion, including the narrowing degree and the length of the narrowed arterial section. It is possible that a narrowed aorta region can impede adequate flow, thereby impacting perfusion to areas distal downstream.

Fig.1 Coarctation of the aorta. (Salciccioli, K. B., and Zachariah, J. P., 2023)

Pathogenesis of Coarctation of the Aorta

The coarctation of the aorta pathophysiology mechanisms is still unresolved and multifactorial. The most common isolated coarctation of the aorta genesis is thought to be the narrowing caused by ductus arteriosus tissue ingrowth when its higher oxygen concentrations. Coarctation of the aorta genesis is shown to have some involvement from abnormal endothelial changes, inflammation, and altered elastic functions. Several particular gene mutations, including mutations in NOTCH1 and FOXC1 genes, contribute to the coarctation of the aorta genesis pathogenesis.

Therapeutics Development for Coarctation of the Aorta

Disclaimer: Protheragen focuses on providing preclinical research services. This table is for information exchange purposes only. This table is not a treatment plan recommendation. For guidance on treatment options, please visit a regular hospital.

Our Services

Integrated with biomarker validation and drug screening tools, we help clients formulate novel therapeutic targets and optimize therapeutics. These technologies, together with our precision modeling of disease processes, advanced diagnostics, and other therapeutic discovery capabilities and services, aim to solve the complex problems of aortic stenosis and its systemic complications.

Therapeutic Development Services

Diverse Platforms

• Small Molecule Drug Development
• Gene Therapy Development
• Therapeutic Peptide Development

• Cell Therapy Development
• Therapeutic Antibody Development
• Therapeutic Protein Development

Animal Model Development for Coarctation of the Aorta

Coarctation of the aorta animal models gives researchers an effective exploration of narrowing arteries and an innovative therapy pathways assessment. We take pride in offering custom animal model development services designed specifically around your requirements that provide accurate, dependable preclinical models for advanced research and profound therapy innovation.

Induced Animal Models

Utilizing a specific approach to partially constricting the thoracic aorta using a ligature or band to induce coarctation of the aorta in animals and replicate critical pathological features.

• Metal wire-induced model
• Teflon gauze ties-induced model

• Silicone vascular occluder-induced model
• Other models

Protheragen possesses expertise in the entire preclinical workflow such as pharmacokinetic/pharmacodynamic (PK/PD) profiling and safety assessments. In collaboration with biopharma and research leaders, we are advancing coarctation of the aorta research with our flexible, robust biotechnological techniques. As your strategic partner in overcoming the complexity of the coarctation of the aorta, contact us today to learn more about how our comprehensive services can support your next innovation.

Reference

• Salciccioli, Katherine B, and Justin P Zachariah. "Coarctation of the Aorta: Modern Paradigms Across the Lifespan." Hypertension (Dallas, Tex.: 1979) 80.10 (2023): 1970-1979.