Microfluidic Neuroinflammation Model Development
Models of microfluidic neuroinflammation develop advanced systems for the study of neuro-immune interactions, anti-neuroinflammatory drug screening, and treatment development for rare neurodegenerative disorders. Drawing from my profound knowledge in devising frameworks aimed at inflammation of the nervous tissues, Protheragen offers tailored microfluidic models and comprehensive aid for faster commercial access of therapeutics for neurological diseases.
Overview of Microfluidic Neuroinflammation Models
Neuroinflammation is an important aspect of the development of uncommon neurologic conditions such as Rasmussen's encephalitis, Aicardi-Goutières syndrome, and adult-onset leukoencephalopathy with axonal spheroids (ALSP). Traditional in vitro systems inadequately model the composite dynamics of immune cells, blood vessels, and neural tissue that actively participate in the neuroinflammatory cascades. Microfluidic models of neuroinflammation overcome these challenges by allowing for physical manipulation of cells and tissues with low flow rates and complex flow patterns, as well as relevant biochemical gradients, thus enabling more accurate simulations of physiological conditions.
Fig.1 Neuroinflammatory pathways implicated in Alzheimer's disease, tauopathies, and Parkinson's disease. (Guzman-Martinez L, et al., 2019)
Applications of Microfluidic Neuroinflammation Models
Microfluidic models of neuroinflammation allow for the study of relationships between the immune and nervous systems throughout the study of various uncommon neurological diseases. Such advanced systems accelerate the testing of immunomodulatory agents, mechanistic studies of neuroinflammatory processes, tailored treatment assessments, developing relevant insights to neuroinflammation-related pathways. Their controlled microenvironments facilitate the real-time observation of immune cell movement, secretion of cytokines, and damage to the neurovascular unit, which helps accelerate the identification of effective treatment strategies and biomarkers for persistent neuroinflammation.
Fig.2 Viral infection induces neuroinflammation in the brain via activation of microglia. (Tamura Y, et al., 2022)
Our Services
Protheragen is a preclinical research serivce provider and a leader in microfluidic neuroinflammation model development. Constructed with unrivaled precision, these microfluidic models enable the screening of anti-neuroinflammatory drugs as well as targeting therapeutics for rare neurological diseases, thereby paving the path towards personalized medicine.
Blood-Brain Barrier (BBB)-Immune Interaction Microfluidic Model Development
The microfluidic systems are provided with subdivided endothelial and immune cell chambers which are separated by permeable membranes allowing them to investigate BBB disruption due to neuroinflammation in real time under attitude flow conditions. Important features include the precise assessment of immune cells transmigration, barrier permeability alteration due to cytokines and evaluation of BBB-stabilizing agents.
3D Neuroimmune Microfluidic Organoid Model Development
Such 3D models combine patient-specific brain organoids and vascularized microglia to simulate complex neuro-immune-vascular interactions in a physiologically relevant microenvironment. The system facilitates the investigation of microglial activation profiles, synaptic pruning, as well as evaluating potential neuroprotective agents, within context-appropriate models of disease.
Infection-Triggered Microfluidic Neuroinflammation Model Development
Developed for the examination of neurotropic pathogen infections, these models include polarized neuronal cultures with specific exposure routes and immune cell recruitment chambers for controllable pathogen access. They enable exact studies of mechanisms of infection-related neuroinflammation such as glial activation, effects of cytokine storms, and treatment strategies.
Advantages of Microfluidic Neuroinflammation Models
- Human-Relevant Biology
- Disease-Specific Customization
- Superior Technical Control
- High-Throughput & Scalability
- Regulatory & Translational Readiness
- Cross-Disciplinary Validation
At Protheragen, every microfluidic neuroinflammation model undergoes thorough validation and is in compliance with international legal and ethical frameworks. Our company holds compliant platforms that facilitate the generation of dependable preclinical information pertaining to critical evaluations such as pharmacodynamic (PD), pharmacokinetic (PK), and toxicology testing. Should you wish to learn more about our services, we invite you to reach out for detailed quotes and information on the offered services.
References
- Guzman-Martinez L, Maccioni R B, Andrade V, et al. Neuroinflammation as a common feature of neurodegenerative disorders[J]. Frontiers in pharmacology, 2019, 10: 1008.
- Tamura Y, Yamato M, Kataoka Y. Animal models for neuroinflammation and potential treatment methods[J]. Frontiers in Neurology, 2022, 13: 890217.