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Microfluidic Model Development

Enabling the modeling of a disease's mechanisms and drug responses in unprecedented resolution based on specific patient's details, microfluidic models have transformed research regarding rare neurological diseases. Protheragen is focused on designing accurate microfluidic models to enhance the preclinical research phases of potential therapies for rare neurological disorders. Our support fosters dependable and relevant research, ensuring an optimized path toward drug development.

Introduction to Microfluidic Models for Rare Neurological Diseases

Microfluidic models mark an advance in the study of rare neurological diseases as they serve as new transformative tools for neuroscientific studies. The systems emulate the microenvironment of neural tissues with great accuracy, thus enabling researchers at various levels to study the mechanisms of the neural diseases, their drug therapies, and cellular interactions in a controlled environment. The most distinguishing features of microfluidic models is their ability to replicate the blood-brain barrier (BBB), neuronal networks, and glial interactions at micro levels.

Microfluidic devices can be used for detection of disease-specific proteins and other macromolecules, disease modeling, and drug development. Fig.1 Microfluidic devices for the detection of disease-specific proteins and other macromolecules, disease modelling and drug development. (Amir S, et al., 2023)

Applications of Microfluidic Models for Rare Neurological Diseases

Microfluidic models revolutionize the study of uncommon neurological disorders because they enable precise modeling of the disease, individualized drug screening, and development of specific treatment strategies. These systems use cells from patients to reproduce neurovascular and neuronal pathologies, and biosensors incorporated into the system monitor the real-time responses of the neurovascular unit to treatment. Especially useful for rare diseases lacking suitable animal model systems, the technology fosters rapid discovery and validation of biomarkers and therapeutics in human-mimetic microenvironments.

Microfluidic devices have a variety of biomedical applications. Fig.2 Biomedical applications of microfluidic devices. (Gharib G, et al., 2022)

Our Services

Protheragen specializes in offering microfluidic model development services for advancing therapies targeted at rare neurological diseases using modern microfluidic technologies. Our highly accurate models facilitate high-throughput drug screening and extensive preclinical studies, which significantly expedites the translation of therapeutics into clinical practice. These models of human physiology enable the innovative approaches in medicine to reduce the use of standard animal experiments aimed at discovering new biomarkers and assessing drug efficacy in tailored treatments.