Brain Organoid Development
Brain organoids, or 3D models of the brain, are created from stem cells. Protheragen is committed to creating state-of-the-art brain organoid models from human iPSC/ESC to improve research and assist in developing therapies for uncommon neurological disorders. Remarkably accurate, these models can serve in investigating the mechanisms of diseases, conducting large-scale drug screening, and tailoring specific medical treatments to individual patients.
Overview of Brain Organoids
Brain organoids are self-organizing, 3D neural structures created from pluripotent stem cells (PSCs), which comprise embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Their functional neural networks, cellular diversity, and human neurodevelopmental capabilities portray miniature brain-like organs. This makes them extremely useful for research on complex neurological disorders which are challenging to study in animal models or two-dimensional cell cultures.
Fig.1 Comparison of human brain organoids and the human brain. (Goddard, Eliza, et al., 2023)
Application of Brain Organoids
Brain organoids are revolutionizing neuroscience since they allow the study of human-specific neural developmental aspects such as mechanisms of disease, responses to drugs, and much more with unparalleled accuracy. These 3D models replicate complex neural structures and are air used to study rare neurological diseases, neurodegenerative diseases, and neuroinfections. They also enable medicine to be customized to the individual patient's needs, as well as drug screening and toxicity testing. Moreover, sophisticated microglia-containing and vascularized organoids enable the study of neuroimmune interplay and the crossing of the blood-brain barrier which greatly increases organs' academic and pharmaceutical applicability.
Fig.2 Application of brain organoids as disease models. (Shou, Yikai, et al., 2020)
Our Services
Focused on providing cutting-edge brain organoid development services, Protheragen aims to accelerate the development of therapies for rare neurological disorders and provide physiologically relevant 3D models for preclinical studies. Our platform utilizes patient-derived iPSCs to generate region-specific organoids that accurately recapitulate disease pathology and enable reliable evaluation of drug efficacy and safety.
Brain Organoid Development Services
Committed to providing end-to-end solutions for brain organoid development, Protheragen supports every step from cell line preparation to preclinical validation. We offer comprehensive customized services to accelerate your research and therapeutic development for rare neurological diseases.
- iPSC Generation & Reprogramming
- Genetic Engineering & Modeling
- Custom Brain Organoid Development
- Phenotypic & Functional Characterization
- Drug Screening & Preclinical Testing
- Multi-Omics & Data Integration
Various Types of Brain Organoids
Protheragen uses human iPSCs/ESCs and a proprietary neural induction protocol to generate region-specific 3D models. Through controlled differentiation and an optimized 3D culture system, we construct structured organoids containing neurons, astrocytes, oligodendrocytes, and optional microglia or vascular cells. These organoids are validated by electrophysiological activity and cellular structure and undergo rigorous quality control.
- Cortical Organoid Development
- Midbrain Organoid Development
- Hypothalamic Organoid Development
- Hippocampal Organoid Development
- Disease-Specific Brain Organoid Development
- Others
Key Features of Brain Organoids
Brain organoids stand out for their region-specific cytoarchitecture, functional neural network activity, and excellent reproducibility. With comprehensive multi-omics validation and scalability for high-throughput applications, our organoids provide researchers with the most translationally predictive tools for studying rare neurological diseases and developing targeted therapies.
- Region-Specific Modeling
- Cellular Complexity
- Disease-Relevant
- Functional Maturity
- High Reproducibility
- Multi-Omics Validation
- Physiological Accuracy
- Scalable Platforms
- Customizable
Protheragen's brain organoid models fully comply with international ethical standards and regulatory guidelines, providing a controlled experimental platform for human-relevant central nervous system (CNS) research. These models are specifically validated for comprehensive pharmacodynamic (PD), pharmacokinetic (PK), and toxicology evaluations. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Goddard, Eliza, et al. "Human brain organoids and consciousness: moral claims and epistemic uncertainty." Organoids 2.1 (2023): 50-65.
- Shou, Yikai, et al. "The application of brain organoids: from neuronal development to neurological diseases." Frontiers in cell and developmental biology 8 (2020): 579659.