Xenograft Model Development Service
Xenograft models have become indispensable tools in rare disease research, particularly in the field of rare oncology. They offer unique advantages in recapitulating human physiology, studying tumor growth and metastasis, evaluating drug efficacy, and enabling personalized approaches. Our company provides comprehensive xenograft model development services. We provide comprehensive reports on therapeutic responses, tumor growth inhibition, and potential adverse effects, helping our clients make informed decisions in their rare disease drug development process.
Overview of Xenograft Models
A xenograft model, also known as a heterograft model, involves the transplantation of cells, tissues, or organs from one species (donor) into another species (recipient) for research purposes. This approach allows scientists to study the behavior of human cells or tissues in a living organism, typically mice or rats, providing valuable insights into human diseases and their drug development.
The choice of host species is crucial for xenograft model construction. Immunocompromised mice, such as nude mice or severe combined immunodeficiency (SCID) mice, are commonly used due to their inability to reject foreign tissues. These strains lack functional T cells, critical for immune responses against transplanted cells or tissues.
Fig.1 Timeline of the PDX study. (Liu, Yihan, et al., 2023)Various techniques can be employed for the implantation of human cells or tissues into the recipient animals. Subcutaneous implantation involves injecting cells or placing tissue fragments under the skin, which is suitable for studying tumor growth and therapeutic interventions. Orthotopic implantation involves transplanting cells or tissues into the anatomically relevant site, allowing researchers to study tumor invasion, metastasis, and response to therapy in the appropriate tissue context.
Types of Xenograft Models
| Animal models | Advantages | Limitation |
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| Cell Line-Derived Xenograft (CDX) Models |
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| Patient-Derived Xenograft (PDX) Models |
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Our Services
At our company, we offer comprehensive xenograft model development services, including subcutaneous transplantation, renal subcapsular transplantation and orthotopic transplantation, to meet the specific needs of researchers and pharmaceutical companies. We assist in establishing the appropriate xenograft model type, selecting the most suitable cell lines or patient-derived tissues, and optimizing the implantation procedure. Our expertise in xenograft models and state-of-the-art facilities enable us to deliver high-quality, reliable preclinical models for rare disease research.
Our company specializes in drug safety evaluation and pharmacokinetics research using xenograft models. We employ sophisticated analytical techniques to measure drug concentrations in plasma and tumor tissues, assess drug metabolism and distribution, and correlate these findings with therapeutic outcomes. These studies provide crucial insights into drug efficacy and optimization.
Why Choose Us?
Our company is deeply committed to advancing the development and application of xenograft models. We offer comprehensive services to both established biopharmaceutical companies and emerging scientific research institutions, aiming to enhance xenograft model development specifically for rare diseases. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Liu, Yihan, et al. "Patient-derived xenograft models in cancer therapy: Technologies and applications." Signal Transduction and Targeted Therapy 8.1 (2023): 160.
- Abdolahi, Shahrokh, et al. "Patient-derived xenograft (PDX) models, applications and challenges in cancer research." Journal of Translational Medicine 20.1 (2022): 206.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
