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One-stop piRNA Research Solutions for Advanced Diagnostic and Therapeutic Development
As a leading provider of piRNA research services, Protheragen is dedicated to accelerating discoveries in epigenetics, disease mechanisms, and therapeutic development. End-to-end solutions are provided by us, from high-throughput sequencing and biomarker identification to diagnostic and therapeutic development. By bridging foundational research with translational applications, we empower clients to unlock the transformative potential of piRNA biology.
One-stop Solution
To support researchers in exploring the potential of piRNAs, we offer comprehensive piRNA research services, from systematic profiling and biomarker discovery to functional characterization.
- piRNA High-Throughput Sequencing Service
- piRNA Array Service
- piRNA Chip Development Service
- piRNA Biomarker Identification Service
- piRNA Target Identification Service
piRNAs are emerging as powerful molecular tools whose unique properties make them ideal candidates for diagnostic and therapeutic development. Protheragen is focused on developing innovative piRNA-based diagnostics and therapeutics targeting cancer, infectious diseases and neurodegenerative diseases.
Case Study-piRNA Profiling in Patients with Heart Failure
To explore the role of piRNAs in heart failure, we compared the serum exosome piRNA profiles of patients and healthy controls. The experimental steps included isolation of exosomes, comprehensive characterization, RNA extraction, and high-throughput sequencing. The results showed that 578 piRNAs were upregulated and 4,617 piRNAs were downregulated in patients with heart failure. Notably, has-piR-020009 and has-piR-006426 were most significantly downregulated, suggesting that they may have biomarker application value.
Fig.1 Differential expression of piRNAs. (HF: heart failure; CON: control.)
Protheragen offers customized piRNA research solutions to meet our clients' specific discovery and development needs. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.