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One-stop Solution for piRNA Research
In order to encourage innovative developments in piRNA research, Protheragen has committed to providing comprehensive research and development services. We specialize in delivering high-quality, accurate support which is designed to meet the requirements of your research swiftly and effectively.
Overview of piRNAs
Piwi-interacting RNAs (piRNAs) are a particular class of small non-coding RNA molecules that have crucial functions in genome defence and germline cell development. These small RNA molecules with a length of 24-31 nucleotides are principally expressed in the germline of animals. PiRNAs bind with PIWI proteins to form ribonucleoprotein complexes that target and silence transposable elements in the genome for genomic stability. Additionally, piRNAs have important roles in genomic defence, epigenetic modifications, and developmental processes of the germline.
Transposon Silencing
Combined with PIWI proteins, piRNAs allow the identification and silencing of transposons, thus protecting the genome from damaging insertions and harmful mutations.
Germline Development
PiRNAs are abundant within germ cells. They are essential to the growth and function of these cells through the regulation of transposable elements and other related genes.
Epigenetic Regulation
There is a suggestion that piRNAs help in establishing and maintaining epigenetic marks that modulate the expression of certain genes and the arrangement of chromatin, thus regulating the functions of genes and the activity of the cell.
Disease Implications
Abnormal expression of piRNA might be linked with several diseases such as cancer. Studying the dysregulation of piRNA in disease conditions could provide useful information for developing new diagnostic and therapeutic strategies.
Significance of piRNA Research
The significance of piRNA research lies in its potential to change our understanding of gene regulation, disease mechanisms, and therapy development for the better. Discovering the roles that piRNAs serve in health as well as disease will aid researchers in developing new diagnostics, biomarkers, and therapeutics for addressing unmet health needs.
Fig 1 Impact of human piRNAs on central nervous system diseases. (Pan, Xian, et al., 2024)
Our Services
To tackle the fundamental difficulties and intricacies of piRNA research, Protheragen is focused on providing a one-stop solution for the researchers. Covering complete research and development services, our solutions include professional support for fundamental biological research, diagnostic, and therapeutic development involving piRNAs.
One-Stop Solution
Starting from high-throughput sequencing, advancing towards biomarker and target identification processes, our customised research services offer a one-stop shop for all your needs.
Development Services
Protheragen's scientists explore potential piRNA biomarkers and targets to advance diagnostics and therapeutic development for a wide range of diseases by delving into disease mechanisms.
Why Choose Us?
Rich Expertise and Experience
Comprehensive and Customized Solutions
Cutting-edge Technology Platforms
Trustworthy and Reliable Partner
Protheragen's solution encompasses an entire range of piRNA research services, enabling scientists to further engage in this particular field of study. If you wish to learn more about our services, please do not hesitate to get in touch with us to obtain additional information and quotes for those services.
Reference
- Pan, Xian, et al. "PIWI-Interacting RNAs: A Pivotal Regulator in Neurological Development and Disease." Genes 15.6 (2024): 653.