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piRNA-Based Diagnostic Development Service
Traditional diagnostic methods such as imaging and serological testing have always faced issues like low sensitivity and unsatisfactory specificity in certain diseases. Hence, there is new and urgent market demand for new biomarkers. Given the characteristics of piRNAs, Protheragen is dedicated to providing piRNA-based diagnostics development services to enhance the accurate diagnosis of multiple diseases.
The Role of piRNA in Disease Diagnosis
piRNAs are a class of small non-coding RNAs involved in the regulation of transposon activity in germline cells. Recently, piRNAs have attracted notable interest for their applications in disease diagnosis. In the context of diagnostics, piRNAs have exceptional qualities that could serve as diagnostic markers in several ailments like cancer, neurodegenerative disorders and metabolic conditions.
Disease-Specific Expression Patterns
Differential expression of piRNAs has been observed between normal tissues and diseased tissues. Such altered expression patterns could be used to pinpoint piRNA signatures that are unique to certain diseases and serve as diagnostic markers for a wide variety of ailments.
Stability and Accessibility
Unlike other RNA molecules, piRNAs have greater stability and are less prone to degradation. Because of these features, they make suitable candidates for diagnostic purposes as they are readily detectable from different biological specimens such as blood and urine.
Regulation of Gene Expression
The role of piRNAs includes the regulation of gene expression at the post-transcriptional level. Irregular piRNA expression can affect the expression levels of target genes that are involved in disease pathways, which provides important insights for disease diagnostic purposes.
Potential for Liquid Biopsies
piRNAs open avenues for liquid biopsies, which are minimally invasive for disease diagnosis. Doctors are able to acquire pertinent information for early diagnosis and monitoring of diseases by assessing piRNA signatures in bodily fluids such as blood or cerebrospinal fluid.
piRNA-Based Diagnostic Development
Although piRNA diagnostic tests are still being developed, emerging research has shown their potential as biomarkers for the diagnosis of multiple diseases. Moreover, the progress of piRNA diagnostics has also been stirred by breakthroughs in other advanced technologies.
- Cancer: Research shows piRNA serves as an important diagnostic or prognostic biomarker in a number of cancers which include breast, lung, and prostate cancer.
- Neurodegenerative diseases: The dysregulation of piRNA in neurodegenerative disorders like Alzheimer's disease and Parkinson's disease offers novel insights for the early diagnosis of these conditions.
- Cardiovascular diseases: The fact that piRNA has a regulatory role in other disease processes such as myocardial infarction and heart failure makes it a potential diagnostic marker.
Technological Breakthrough
- High-throughput sequencing technology: Next-generation sequencing (NGS) technology has been an enabler for the large-scale profiling of piRNA biomarker discovery due to its unprecedented piRNA expression analysis.
- Liquid biopsy technology: The detection of piRNAs in blood and urine samples enables the non-invasive, real-time diagnosis and monitoring of diseases.
- Artificial intelligence and big data analysis: With the integration of machine learning algorithms, researchers can analyze extensive piRNA data and automate the detection of critical diagnostic features, thus improving the reliability of diagnostic models.
Our Services
At Protheragen, we seek to leverage piRNA for the development of advanced diagnostic solutions that will transform disease detection and management. With a focus on high-throughput sequencing, microarray technology, artificial intelligence, and big data analytics, we have made it our mission to discover specific piRNA biomarkers for diagnostic tests that meet the expanding need for accurate, early, and non-invasive diagnostic tools for a variety of ailments.
piRNA Detection Kit Development
Protheragen specializes in designing advanced kits that are specifically aimed at providing precision detection of piRNA biomarkers from diverse biological samples like blood, urine and tissues in a reliable and cost-effective way.
piRNA Point-of-Care Testing (POCT) Development
Our piRNA POCT solutions are intended to make piRNA diagnostics available at the point of care, whether that is a bedside, clinic, or field location. These easy to use and fast diagnostic tools allow for in-the-moment decision-making and piRNA detection in real-time.
piRNA Companion Diagnostic Development
The service intends to integrate piRNA biomarkers into the clinical decision-making systems. Our companion diagnostic solutions are aimed at augmenting the effectiveness of therapeutic interventions and formulating personalized therapeutic approaches.
Diagnostic Development for Multiple Diseases
| Category | Diseases | |
| Cancer |
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| Neurological Disorders |
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| Cardiovascular Diseases |
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| Infectious Diseases |
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| Genetic Diseases |
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| Metabolic Disorders |
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Protheragen focuses on using the detection potential of piRNAs to develop diagnostics for enhanced early disease identification, disease classification, prognosis, and tailored therapeutic plans. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Qu, Ailin, et al. "A serum piRNA signature as promising non-invasive diagnostic and prognostic biomarkers for colorectal cancer." Cancer management and research (2019): 3703-3720.