piRNA-Based Therapeutic Development Service
Therapies based on piRNAs offer a new paradigm in the management of complex disorders. piRNA-based therapeutic development services offered by Protheragen are leading this innovation by allowing researchers to capitalize on piRNAs for transformative therapeutics. As your trusted partner, we support you through the entire process of bringing your piRNA therapeutics to market.
piRNA and Disease Therapeutics
Given their important functions in gene expression and ensuring stability of the genome, piRNAs offer a novel and exciting approach for drug discovery for treating diseases. The use of piRNAs to target specific genes provides effective therapeutics of diseases that stem from piRNA dysfunction. At this point, piRNAs have shown promise in the therapeutics of complicated diseases like cancer, neurodegenerative disorders, infectious diseases, reproductive system ailments, cardiovascular diseases, etc.
Fig 1 Therapeutic potential of piRNAs in multiple cardiovascular diseases. (Li, Min, et al., 2021)
piRNA-Based Therapeutic Development
The benefits of piRNA-based therapy stem from their high specificity to target complementary sequences and significantly reduce off-target effects associated with conventional therapeutics. The diverse and evolutionary conserved functions of piRNAs in various diseases, along with the possibility for tailored precision medicine approaches, make piRNA a desirable candidate for new innovative therapeutic methods. One of the most important strategies in developing piRNA-based therapies is the synthesis of piRNA mimics or inhibitors.
piRNA Mimics
Synthetic piRNA mimics attempt to replicate the structure and function of endogenous piRNAs in order to target certain genes or pathways associated with diseases for expression modulation.
piRNA Inhibitors
piRNA inhibitors seek to interfere with the function of piRNAs associated with diseases, thereby sabotaging detrimental processes of gene regulation, which could stop the disease from worsening.
Our Services
At Protheragen, we are at the leading edge of piRNA-based therapeutic development, providing services that utilize piRNAs for novel therapeutic approaches. With our specialized experience in synthetic piRNA mimics and inhibitor design, we are able to custom precision therapies that aim at the specific disease pathways on a whole new level of personalized medicine.
Therapeutic Development for Multiple Diseases
Reproductive Disease
Therapy Development
Cardiovascular Disease
Therapy Development
Metabolic Disease
Therapy Development
Service Workflow
Consultation and
Project Planning
piRNA Molecule
Design
Delivery System
Optimization
Mechanistic Studies
and Optimization
Protheragen's goal is to support basic and applied research in piRNA biology to generate new insights into the roles of piRNAs in health and disease and to provide new tools and targets for piRNA research, diagnostics, and therapeutics. Contact us today to discuss your project and learn how we can support your research goals.
Reference
- Li, Min, et al. "Piwi-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases." Angiogenesis 24 (2021): 19-34.