Online Inquiry
Alogliptin
Cat. No. IC23067
CAS. No. 850649-61-5
Key Features and Details
Category
Inhibitor&Activator
Purity
99.92%
Formula
C18H21N5O2
Product Details
Product Name
Alogliptin
CAS No.
850649-61-5
Molecular Weight
339.39
Target
DPP-4
Synonyms
SYR-322 free base
Formula
C18H21N5O2
Appearance
Solid
Purity
99.92%
IC50/EC50
IC50: <10 nM
SMILES
O=C(C=C(N1C[C@H](N)CCC1)N(C2=O)CC3=C(C#N)C=CC=C3)N2C
Product Overview
Description
Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes.
In Vitro Activity
Alogliptin (1 nM; 5-60 min) inhibits LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation in U937 cells.
Alogliptin (0.5-5 nM; 24 h) inhibits LPS-stimulated MMP-1 secretion and mRNA expression that is mediated by ERK pathway in U937 cells.
In Vivo Activity
Alogliptin (0.01-1 mg/kg) produced dose-dependent improvements in glucose tolerance and increased plasma insulin levels in female Wistar fatty rats.
Alogliptin (40 mg/kg/day for 2 weeks) reduces infarction area and improves brain vascular integrity in middle cerebral artery occlusion (MCAO) mice.
Storage & Handling
Storage
Powder, -20 °C, 3 years; 4 °C, 2 years
In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Related Products