Hepcidin Modulators Development Service
Iron is a vital mineral, but its physiological deregulation can produce a broad spectrum of health problems, from anemia to iron excess. The primary regulator of systemic iron homeostasis is hepcidin, a key hormone. Protheragen provides an all-in-one solution for hepcidin modulators research and development for the nutraceutical industry, featuring natural compounds and formulation development to safely and efficaciously modulate hepcidin; thereby, promoting normal iron metabolism for their health and wellness applications.
Introduction to Hepcidin Modulators
Hepcidin regulates iron absorption, recycling, and release, thereby influencing iron balance. The complexity of the role of hepcidin renders it a very interesting candidate target for nutraceutical interventions to optimize iron metabolism. Hepcidin modulators are compounds that can affect the synthesis, function, or degradation of hepcidin and thus influence iron metabolism. That presents a viable route to maintain balanced iron levels naturally, addressing the growing demand for proactive and preventive health solutions.
Fig.1 Key functions of hepcidin. (Nemeth, E., and Ganz, T., 2023)
In the field of nutraceuticals, such modulators usually originate from natural sources, including:
- Botanical extracts: Some plants possess phytochemicals that could interfere with iron metabolism pathways.
- Vitamins and minerals: There are some vitamins and minerals with an indirect influence on hepcidin expression and iron absorption.
- Bioactive peptides: Peptides derived from food sources may exhibit modulatory effects.
- Probiotics: The intestinal microbiota may modulate iron absorption and systemic inflammation with an associated impact on hepcidin levels.
Fig.2 Molecular regulation of hepcidin expression. (Nemeth, E., and Ganz, T., 2023)
Categories of Hepcidin Modulators
- Hepcidin Agonists
These molecules are designed to stimulate the expression or activity of hepcidin, which results in the reduction of iron absorption and release. This can be useful for those who are at risk for mild iron overload or who are looking to control their iron levels more strictly.
- Hepcidin Inhibitors
These are intended to reduce the production or action of hepcidin, which would in turn generate more efficient iron absorption and availability. This may be of benefit to those with mild iron deficiency or who are looking to increase iron absorption.
Our Services
At Protheragen, we provide one-stop iron metabolism-related nutraceutical development services. We have extensive experience in the development of hepcidin modulators and provide comprehensive services to researchers and entrepreneurs from concept all the way to market, to develop with rigor and scientific validity, and to meet the standards of the nutraceutical sector.
Types of Hepcidin Modulators Development
| Categories | Description | Active Ingredients |
| Hepcidin Agonists | Promote hepcidin expression to aid iron redistribution. | Quercetin, Melatonin, Curcuminoids, Resveratrol, etc. |
| Hepcidin Inhibitors | Temporarily support hepcidin downregulation to optimize iron absorption. | Green Tea EGCG, Bovine Lactoferrin, Silybin (Milk Thistle), etc. |
Hepcidin Modulators Development Services
Nutraceutical Formulation Development
Expertise in developing optimal and stable formulations for your hepcidin modulating nutraceuticals, including optimization of excipient, dosage form, and product stability.
Nutraceutical Safety Testing Service
Conduct in vitro and in vivo safety screens to identify any potential toxicity, allergenicity, or interactions according to nutraceutical industry standards.
Nutraceutical Efficacy Testing
Testing the nutraceuticals' influence on hepcidin and possibly iron status can be achieved by applying appropriate in vitro assays or preclinical disease models of iron metabolism.
Nutraceutical Bioavailability Studies
Perform nutraceutical bioavailability studies to determine the ADME of hepcidin-modulating ingredients, identifying optimal combinations
Nutraceutical Stability Testing
Get a thorough stability test under different environmental conditions, such as temperature, humidity, and light, to verify the integrity, potency, and shelf life.
Other Services
Moreover, we offer other services tailored to aid in the development of your hepcidin modulator nutraceutical from concept to market.
Workflow of Hepcidin Modulators Development Services
Collaborate with Protheragen today to harness the power of hepcidin modulation in the nutraceuticals space. With our assiduous specialization in iron metabolism research and nutraceutical innovation, we positioned you with the competitive edge required to develop groundbreaking and effective health products related to iron metabolism. Reach out to us to talk about your hepcidin modulators development project.
Reference
- Nemeth, Elizabeta, and Tomas Ganz. "Hepcidin and Iron in Health and Disease." Annual review of medicine 74 (2023): 261-277.