Iron Metabolism-related Protein Services

Iron is essential for the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental and can lead to a variety of diseases. Recent advances in iron metabolism research have revealed a variety of complex pathways and proteins that are essential for maintaining iron homeostasis. Protheragen offers a variety of protein analysis services to help our clients delve into the physiological mechanisms associated with iron metabolism.

Roles of Iron Metabolism-related Proteins

Ferritin is the major form of intracellular iron storage and an important component of intracellular iron homeostasis. It encapsulates iron atoms in a spherical shell containing a large central cavity arranged in 24 subunits, which isolates iron ions that can damage cells from intracellular structures while forming an intracellular iron reservoir for biological use.

The iron cycle ^[1].

In the acidic endosome, Fe³⁺ is released from transferrin (Tf) and free Fe³⁺ is reduced to Fe²⁺ by six-transmembrane epithelial antigen of prostate 3 (STEAP3) and transported to the cytoplasm by divalent metal transporter 1 (DMT1) and ZIP8/14. Poly-(rC)-binding protein 1 (PCBP1) and PCBP2 are cytosolic iron chaperones that deliver Fe²⁺ to apo-proteins (metallation), such as hypoxia-inducible factor (HIF) prolyl hydroxylases, ferroportin (iron export), and ferritin (oxidation to Fe³⁺ and storage).

Our Services

Protheragen has been dedicated to protein-related research for many years and has a complete protein assay platform and equipment to provide diversified protein assay solutions according to different needs of our customers. We will tailor our technical solutions to meet the specific needs of our customers to solve all their problems in iron metabolism related protein analysis.

---

Features

Protheragen has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with iron metabolism related protein-based services. If you have any needs, please contact us.