Nutraceutical Bioavailability Studies

In the active area of iron metabolism research, the effectiveness of nutraceutical interventions depends on their bioavailability, which is how effectively the active ingredients are taken up and used by the body. At Protheragen, we recognize this urgent requirement. We provide nutraceutical bioavailability testing service, which offers complete and informative results to help researchers and developers in their work to bring iron metabolism-related nutraceutical products from the concept to the market.

Introduction to Nutraceutical Bioavailability Studies

Bioavailability is defined as the proportion of an ingested nutrient or bioactive compound that gets absorbed into systemic circulation and arrives at the target site in the body to exert physiological effects. In nutraceuticals, where health-giving compounds from food (curcumin, resveratrol, etc.), intervention can depend heavily on bioavailability. At the same time, low bioavailability can make even powerful nutraceuticals useless, for reasons such as poor solubility, instability in the gut, or quick metabolism. Hence, bioavailability studies between in vitro activity and in vivo health effects are essential.

Fig.1. In vivo/in vitro bioavailability evaluation methods. (Prashansa, and Yadav, N., 2024)

Bioavailability Studies for Iron Metabolism-Related Nutraceuticals

Bioavailability testing of iron metabolism-associated nutraceuticals is an essential research field that measures the extent to which different iron-specific nutraceuticals can be absorbed, distributed, metabolized, and become physiologically active.

By using isotope-labeled techniques, Caco-2 cell models, and human studies on controlled iron absorption, researchers can measure key parameters like plasma iron kinetics alongside its incorporation into erythrocytes and ferritin levels. These studies are responsible for determining comparative bioavailability and are helpful in formulation refinement aimed at conditions such as iron deficiency anemia or iron overload disorders, thus proving the efficacy and safety of evidence-based nutraceuticals.

Our Services

To know how efficiently the active ingredients in a nutraceutical are absorbed and utilized by the body, we utilize a variety of advanced technologies and methodologies to test bioavailability that can be customized to the specific characteristics of your nutraceutical and study design. Our methodologies include both in vitro and in vivo models for full assessment, which may be used to tailor the formulation for increased absorption and ensure that consumers receive the maximum benefit from the product.

Nutraceutical Types for Bioavailability Studies

• Iron Supplements Development
• Hepcidin Modulators Development
• Iron Chelators Development
• Antioxidants Development
• Iron Absorption Enhancers Development
• And More

Bioavailability Enhancement Studies

Utilizing advanced technology to effectively enhance the bioavailability of nutraceuticals by breaching the barriers and optimizing the formulation strategy.

• Emulsions
• Liposomes
• Microcapsules
• Others

Nutraceutical Bioavailability Study Services

We provide end-to-end bioavailability research services to optimize the absorption and efficacy of your iron-related nutraceutical products. Maximum concentration (C_max), time to reach maximum concentration (T_max), and area under the curve (AUC) are determined to obtain bioavailability, which is critical for evaluating the efficacy of formulation strategies.

Understand that each nutraceutical project is unique, Protheragen's study solutions are meticulously tailored to your specific product and research objectives. Collaborate with us to realize the full potential of your iron metabolism-related and other nutraceuticals. Talk to us about your bio-availability study requirements and gain speed in developing and researching your nutraceuticals.