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Nutraceutical Efficacy Testing Service

The nutraceutical market is growing rapidly due to an increase in public interest in holistic health and disease prevention, especially with iron metabolism-modulating nutraceuticals. Protheragen's nutraceutical efficacy studies services are intended to offer comprehensive assessments of your iron metabolism-related nutraceuticals comprehensive assessments. We assist researchers and innovators in studying the health benefits and modes of action of their products and achieving high standards in safety and efficacy.

Overview of Nutraceutical Efficacy Testing

Nutraceutical efficacy testing is multifaceted research focused on measuring and quantifying the specific biological impacts a dietary supplement or functional food ingredient has. Efficacy testing goes beyond basic quality control testing, answering the vital question, "Is a desired biological effect achieved with this product in a pertinent biological system?" The science of efficacy testing of nutraceuticals is growing continuously.

Validation parameters for nutraceutical organ-on-chip models. Fig.1 Essential parameters in nutraceutical organ-on-chip systems. (Farooqi, M. A., et al., 2023)

Efficacy Testing for Iron Metabolism-related Nutraceuticals

Dysregulation of iron metabolism results in a range of diseases, ranging from anemia, the most widespread nutritional disorder in the world, to iron overload diseases such as hemochromatosis. Nutraceuticals engineered to influence iron metabolism may represent new strategies in managing these diseases. But in order for these products to be trusted by consumers and scientifically well-prepared, strict testing should be applied and should be practiced on the effectiveness of the nutraceuticals.

In the case of iron-related nutraceuticals, effectiveness evaluation is based on a standard analysis of how the product may exert a beneficial influence on iron balance. This can involve an evaluation of:

Iron Storage and Mobilization
Assessing the impacts on iron storage and mobilization by monitoring changes in ferritin or other protein levels.
Red Blood Cell Parameters
Relevant shifts in the hemoglobin, hematocrit, and erythrocyte population metrics in relation to anemia.

Specific Iron-Related Proteins and Pathways
Assessment of changes in specific proteins such as hepcidin, ferroportin, and transferrin.
Markers of Oxidative Stress and Inflammation
Evaluation of some oxidative stress markers, such as MDA, as well as activities of some antioxidant enzymes like SOD.

Our Services

As a leading iron metabolism research service provider, we provide you with all-around and one-stop services for the development and validation of nutraceuticals that target iron metabolism. Our nutraceutical effectiveness testing services are customized to fit your product and research requirements, to optimize the potential of nutraceutical products.

Nutraceutical Types for Efficacy Testing

Optional Models in Nutraceutical Efficacy Testing

Furthermore, we have advanced in vitro and in vivo models for rigorous testing in controlled systems to confirm that products deliver their intended benefits.

In Vitro Testing

This initial step allows for the application of sophisticated analytical techniques in a controlled laboratory environment, providing an assessment of mechanisms of action and bioavailability (e.g., iron solubility, cellular uptake) and observing cellular effects at the cellular level.

Optional In Vitro Models:

In Vivo Testing

Building upon the positive effects seen in vitro, in vivo testing provides a more holistic appraisal of the effects of systemic processes, safety, and final effectiveness in a living organism with complex iron homeostasis, for instance.

Optional Animal Models:

Collaborate with the experts at Protheragen for comprehensive, scientifically validated nutraceutical effectiveness testing that provides you with reliable results to support your market strategy, ensures your product meets industry and consumer expectations, and helps advance human health with proven nutritional solutions. Are you ready to take your nutraceutical research to the next level? Get in touch with us today to discuss your project and for a bespoke solution!

Reference

Farooqi, Muhammad Awais et al. "Organ-on-Chip: Advancing Nutraceutical Testing for Improved Health Outcomes.” ACS omega 8.35 (2023): 31632-31647.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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