Antioxidants Development Service
Iron is an essential mineral involved in several biological processes. Nevertheless, dysregulation in iron metabolism can result in the imbalance of reactive oxygen species (ROS) that would give rise to oxidative stress. Such oxidative stress is involved in the pathogenesis and exacerbation of diverse diseases concerning iron metabolism. Protheragen is a one-stop research service supplier for iron metabolism disorders, providing a one-stop solution in iron metabolism-related nutraceutical development, including antioxidant development.
Introduction to Antioxidants
Antioxidants are the substances that inhibit or delay the cellular damage and peroxidation of lipids due to ROS. In the process of iron metabolism, antioxidants are capable of reducing the adverse effects of iron-induced oxidative stress and providing health support as well as management tools for iron-related disorders.
Fig.1 Modulation by melatonin in iron overload-induced oxidative damage. (Yang, J., et al., 2022)
Either excessive or mismanaged iron can induce the formation of highly reactive free radicals like the hydroxyl radical. These free radicals are capable of impairing important cellular components, including lipids, proteins, and DNA, and thus elicit inflammation, cellular dysfunction, and disease development. Antioxidants work by:
- Neutralizing oxidative stress: Neutralize reactive oxygen species (ROS) such as hydroxyl radicals produced from the labile iron.
- Protecting Cellular Components: Protect lipids, proteins, and DNA from oxidative damage.
- Chelating Excess Iron: Some antioxidants can bind to iron, thus preventing it from participating in pro-oxidant reactions.
Classification of Antioxidants in Nutraceuticals
Enzymatic Antioxidants
These are enzymes which naturally present in the body and can transform toxic oxidative products into their less harmful form. They can be superoxide dismutase (SOD) mimics/boosters, catalase (CAT) support, and so on.
Non-enzymatic Antioxidants
These are exogenous compounds that can be received from daily meals or supplements. They can also be divided into vitamins (vitamin C, vitamin E), minerals (Selenium, Zinc), polyphenols, carotenoids, and others as described above.
Our Services
At Protheragen, we provide a full spectrum of antioxidant nutraceutical discovery and development services, particularly for iron metabolism-related nutraceuticals. Our knowledge in iron metabolism, along with our extensive expertise in nutraceutical development, capable us to create novel and effective customized solutions for our customers.
Types of Antioxidant Development
| Types | Description |
| Free Radical Scavengers | These nutraceuticals contain materials that directly neutralize reactive oxygen species, thus preventing cellular damage. |
| Chelating Antioxidants | Focused on ingredients with mild iron-chelating properties that can modulate the labile iron pools and decrease iron-catalyzed free radical formation. |
| Endogenous Antioxidants | These nutraceuticals try to increase the natural production or activity of endogenous antioxidant enzymes and molecules. |
| Mitochondria-targeted Antioxidants | With a focus on preserving mitochondrial function, as these are key sites for ROS production, and are highly susceptible to oxidative damage. |
One-stop Antioxidants Development Services
Our antioxidants development covers a variety of key areas to help you research and develop a successful nutraceutical.
It is essential to optimize the formulation of your antioxidant nutraceutical. This includes carefully considering ingredient compatibility, stability, and the most effective target delivery method, whether it's capsules, powders, or liquids.
Nutraceutical Safety Testing Service
Thorough safety testing is conducted to ensure your antioxidant nutraceutical is safe to consume. These evaluations cautiously scrutinize the toxicity, side effects, and interactions with other chemicals.
Nutraceutical Efficacy Testing Service
It is critical to be stringent in assessing your antioxidant nutraceutical's efficacy. We concentrate on its potential for reducing oxidative stress associated with iron metabolism, and report evidence that it may have a protective role against cellular damage.
Nutraceutical Bioavailability Studies
Defining the bioavailability of active antioxidant components is vital to the success of the product. Research done shows the extent of absorption and utilization of the compound, which helps in assuring that the nutraceutical achieves its claimed health benefits.
Nutraceutical Stability Testing Service
We perform accelerated and real-time stability testing to determine the exact shelf life of your antioxidant nutraceutical. This strict protocol ensures the product's quality and integrity throughout its shelf life, guaranteeing consistent quality and potency.
Workflow of Antioxidants Development Services
Collaborate with Protheragen on the most advanced antioxidant nutraceuticals to address the problems with iron metabolism associated with oxidative stress. Get in touch to find out how we can drive forward your research and development programs.
Reference
- Yang, Jiancheng et al. "Melatonin: Potential avenue for treating iron overload disorders." Ageing research reviews 81 (2022): 101717.