Anti-Aging Product Development Service
Iron metabolism is important in skin aging. Free iron in excess accelerates the generation of reactive oxygen species (ROS) via the Fenton reaction, and plays a major role in oxidative stress, the degradation of collagen, and cellular ferroptosis, a key motive in ageing. Protheragen is committed to promoting research into iron metabolism and is experienced in diagnostics and therapeutic preclinical studies for iron metabolism-related disease. Based on these competences, we offer services for iron metabolism-related cosmetics formulation development, focusing especially on anti-aging products.
Overview of Anti-Aging Products
Iron is a requisite trace nutrient; nonetheless, its misregulation can have profound effects on cellular aging. If the iron metabolism rates are unbalanced (due to a defect in iron uptake, iron accumulation, or hormones related to iron metabolism), either iron overload or iron deficiency occurs.
- Increased Oxidative Stress
Iron overload can trigger reactive oxygen species (ROS) production, which attack DNA, proteins, and lipids, and thus promote the cellular senescence and aging of skin.
- Collagen and Elastin Degradation
Oxidative stress and inflammation associated with iron metabolism imbalance can break down collagen and elastin fibers, resulting in wrinkles, fine lines, and loss of skin's elasticity.
- Inflammation
Those imbalanced iron levels can lead to persistent low-grade inflammation in the skin, accelerating ageing and predisposing the skin to myriad skin problems.
- Mitochondrial Dysfunction
Iron is an essential element in mitochondrial function. Its dysfunction can affect the energy generation of mitochondria, and affect the growth, regeneration of cells.
Fig.1 Schematic of the cutaneous redox equilibrium. (Pourzand, C., et al., 2022)
Effects of Iron Metabolism-related Anti-Aging Products
Anti-aging cosmetics targeting iron metabolism are intended to regulate iron homeostasis in the skin and protect it from aging. These are products using the latest and best in science to balance iron homeostasis, combat oxidative damage, and visibly rejuvenate skin.
- Reduce Oxidative Damage: By chelating excess iron or enhancing antioxidant defense mechanisms.
- Promote Collagen and Elastin Synthesis: With the promotion of a healthy cellular environment and supporting fibroblast activity.
- Reduces Inflammation: By suppressing iron imbalance-induced inflammation responses.
- Enhance Cellular Regeneration: By optimizing mitochondrial function and promoting healthy cell turnover.
Our Services
By understanding and targeting the iron-related pathways, we provide innovative anti-aging cosmetic development solutions that go beyond conventional approaches. Our company provides full support from concept to market for the development of anti-aging cosmetics in relation to iron metabolism, and strives to support researchers and companies to develop novel and effective products for the beauty industry.
Anti-Aging Product Development Services
Our approach is carefully staged to ensure a combination of scientific integrity and commercial viability.
Ingredient Selection
- Target Identification & Mechanism Exploration: In-depth research in specific iron metabolism pathways of interest for modulating the aging process.
- Ingredient Vetting: Discovery and validation of new actives with documented efficacy in the modulation of iron homeostasis.
- Prototype Development: Development of initial product formulations from research.
- Inside Review & Feedback: Once the prototype is prepared, cosmetic developers and marketers review the product and provide feedback on the cosmetic for improvement, and make a new prototype for testing.
In Vitro and In Vivo Evaluation
- Cosmetic Efficacy Testing: Proof of anti-aging efficacy through established aging models such as induced oxidative stress and UV Stress.
- Cosmetic Safety Testing: Comprehensive safety assessment for any possible adverse effects to consumers.
- Stability Testing for Cosmetics: Identifying product stability and performance in different conditions.
- Microbiology Testing for Cosmetics: Identifying the presence of microbial contamination in cosmetics and ensuring product purity and consumer health.
Regulatory & Commercialization Support
- Regulatory Compliance Guidance: Assuring all R&D processes and product formulations comply with global cosmetics regulations.
- Claim Substantiation: Providing scientific data to support product claims for marketing and branding.
Collaborate with Protheragen to innovate in the anti-aging cosmetic market. With expertise in iron metabolism and extensive development capabilities, we are your partner in developing truly ground-breaking anti-aging products. Get in touch with us about your anti-aging product development requirements and find out how we can work together to bring your vision to life!
Reference
- Pourzand, Charareh et al. "Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants." Antioxidants (Basel, Switzerland) 11.3 (2022): 471.