Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
Disease Area
Aceruloplasminemia, an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
Sequence Similarities
Belongs to the multicopper oxidase family.
Storage & Handling
Storage
Store at -20°C. Avoid freeze/thaw cycles.
Storage Buffer
0.01M TBS (pH7.4) with 1% rAlbumin, 0.03% Proclin300 and 50% Glycerol
Shipping
Shipped at 4°C
Form/Appearance
Liquid
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