Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385).
The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity).
Disease Area
Spondylometaphyseal dysplasia, Sedaghatian type (SMDS)
Sequence Similarities
Belongs to the glutathione peroxidase family.
Storage & Handling
Storage
Store at -20°C. Avoid freeze/thaw cycles.
Storage Buffer
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH 7.3 with 0.5% bovine serum albumin.
Shipping
Shipped at 4°C
Form/Appearance
Liquid
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