Product Name
Human Apoptosis-inducing factor 2 (AIFM2) ELISA Kit
Product Alternative Names
Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death; p53-responsive gene 3 protein
Reactivity
Human
Sensitivity
0.115 ng/mL
Detection Range
0.312-20 ng/ml
Assay Type
Sandwich
Description
The product is designed for analyse the presence of the target Apoptosis-inducing factor 2 (AIFM2) in Human biological samples using enzyme-linked immunosorbent assay technology.
Sample Type
Serum, Plasma, Cell Culture Supernatants, Body Fluid and Tissue Homogenate.
Notes
For research use only.
Applications
ELISA
Gene Symbol
AIFM2
Related Gene ID
Gene Name
apoptosis-inducing factor, mitochondrion-associated, 2
Alias Symbols
AIFM2; AMID; PRG3; RP11-367H5.2
Protein Name
Ferroptosis suppressor protein 1
Related Uniprot ID
Molecular Weight
40.5 kDa
Sequence Similarities
Belongs to the FAD-dependent oxidoreductase family.
Tissue Specificity
Heart.
Cellular Localization
Cell membrane, Cytoplasm, Lipid droplet, Membrane, Mitochondrion and Nucleus.
Function
A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis (PubMed:31634899, PubMed:31634900, PubMed:35922516).
At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis (PubMed:31634899, PubMed:31634900).