Product Name
Human Hereditary Hemochromatosis Protein (HFE) ELISA Kit
Reactivity
Human
Description
The kit is designed to analyse the presence of the target Hereditary Hemochromatosis Protein (HFE) in Human biological samples using enzyme-linked immunosorbent assay technology.
Notes
For research use only.
Applications
ELISA
Gene Symbol
HFE
Related Gene ID
Gene Name
homeostatic iron regulator
Alias Symbols
HFE1, TFQTL2, HH, HLA-H, MVCD7
Protein Name
Hereditary hemochromatosis protein
Related Uniprot ID
Molecular Weight
40,534 Da
Sequence Similarities
Belongs to the MHC class I family.
Tissue Specificity
Expressed in all tissues tested except brain.
Cellular Localization
Cell membrane and Membrane.
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Disease Area
Hemochromatosis 1 (HFE1), a disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.