Product Name
Mouse CDGSH iron-sulfur domain-containing protein 2 (CISD2) ELISA Kit
Reactivity
Mouse
Detection Range
0.156-10 ng/ml
Assay Type
Quantitative
Description
Mouse CDGSH iron sulfur domain 2 containing protein 2 (CISD2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse CDGSH iron sulfur domain 2 containing protein 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Sample Type
Tissue Homogenates, Cell Lysates and Other Biological Fluids.
Notes
For research use only.
Applications
ELISA
Gene Symbol
CISD2
Related Gene ID
Gene Name
CDGSH iron sulfur domain 2
Alias Symbols
ERIS; WFS2; ZCD2; NAF-1; Miner1
Protein Name
CDGSH iron-sulfur domain-containing protein 2
Related Uniprot ID
Molecular Weight
15 kDa
Sequence Similarities
Belongs to the CISD protein family. CISD2 subfamily.
Tissue Specificity
Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets.
Cellular Localization
Endoplasmic reticulum, Membrane and Mitochondrion.
Function
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Disease Area
Wolfram syndrome 2 (WFS2).