Product Name
Mouse Hemochromatosis (HFE) Monoclonal Antibody
Description
Mouse monoclonal antibody to HFE.
Species/Host
Mouse
Isotype
IgG1
Clonality
Monoclonal
Conjugation
Unconjugated
Immunogen
Purified recombinant fragment of human HFE expressed in E. coli.
Reactivity
Human
Target
HFE
Gene Name
homeostatic iron regulator
Gene Abbr.
HFE
Gene ID
UniProt ID
Molecular Weight
40 kDa
Alternative Names
HH, HFE1, HLA-H, MVCD7, TFQTL2, MGC103790, dJ221C1
Cellular Localization
Cell membrane.
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Disease Area
Hemochromatosis 1 (HFE1), a disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.
Sequence Similarities
Belongs to the MHC class I family.