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Necrostatin-1
Cat. No. IC23026
CAS. No. 4311-88-0
Key Features and Details
Category
Inhibitor&Activator
Purity
99.82%
Formula
C13H13N3OS
Product Details
Product Name
Necrostatin-1
CAS No.
4311-88-0
Molecular Weight
259.33
Target
RIP1 Kinase
Synonyms
Nec-1
Formula
C13H13N3OS
Appearance
Solid
Purity
99.82%
IC50/EC50
EC50: 182 nM
SMILES
O=C(C(CC1=CNC2=C1C=CC=C2)N3)N(C)C3=S
Product Overview
Description
Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor.
In Vitro Activity
Necrostatin-1 (Nec-1) efficiently inhibits the TNFα-induced necrotic death of L929 cells, which does not require exogenous caspase inhibitors.
Necrostatin-1 (Nec-1) prevents radiocontrast media (RCM)-induced dilation of peritubular capillaries, suggesting a novel role unrelated to cell death for the RIP1 kinase domain in the regulation of microvascular hemodynamics and pathophysiology of contrast-induced AKI (CIAKI).
Necrostatin-1 (Nec-1) (30 µM) increases the survival of cardiomyocyte progenitor cell (CMPCs) by inhibiting necrotic cell death.
In Vivo Activity
Necrostatin-1 (Nec-1) induces tubular bilation and affects the kinetics of the dilation of peritubular capillaries after RCM application. Upon a single intraperitoneal application of a single dose of Necrostatin-1 15 minutes before RCM, the return to baseline levels is prevented within the observation period.
Storage & Handling
Storage
Powder, -20 °C, 3 years; 4 °C, 2 years
In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
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