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Rosiglitazone Potassium
Cat. No. IC23078
CAS. No. 316371-84-3
Key Features and Details
Category
Inhibitor&Activator
Formula
C18H18KN3O3S
Product Details
Product Name
Rosiglitazone Potassium
CAS No.
316371-84-3
Molecular Weight
395.52
Synonyms
BRL 49653 potassium
Formula
C18H18KN3O3S
SMILES
CN(C1=NC=CC=C1)CCOC2=CC=C(C=C2)CC3SC([N-]C3=O)=O.[K+]
Product Overview
Description
Rosiglitazone (BRL 49653) potassium is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone potassium is a TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone potassium can be used in the research of obesity and diabetes, senescence, ovarian cancer.
In Vitro Activity
Rosiglitazone potassium (0.1-10 μM, 72 h) results in pluripotent C3H10T1/2 stem cell differentiation to adipocytes.
Rosiglitazone potassium (1 μM, 24 h) activates PPARγ, which binds to NF-α1 promoter to activate gene transcription in neurons.
Rosiglitazone potassium (1 μM, 24 h) protects Neuro2A cells and hippocampal neurons against oxidative stress, and up-regulates BCL-2 expression in an NF-α1-dependent manner.
Rosiglitazone potassium (0.01-100 μM, 15 min) inhibits TRPM3 with IC50 values of 9.5 and 4.6 μM against nifedipine- and PregS-evoked activity respectively.
Rosiglitazone potassium (0.5-50 μM, 7 days) inhibits ovarian cancer cell proliferation.
Rosiglitazone potassium (5 μM, 7 days) suppresses Olaparib‑induced alterations of cellular senescence and promotes apoptosis in A2780 and SKOV3 cells.
In Vivo Activity
Rosiglitazone potassium (oral administration, 5 mg/kg, daily for 8 weeks) decreases the serum glucose in diabetic rats.
Rosiglitazone potassium (intraperitoneal injection, 3 mg/kg/day) ameliorates airway inflammation induced by cigarette smoke via inhibiting the M1 macrophage polarization by activating PPARγ and RXRα in male Wistar rats.
Rosiglitazone potassium (intraperitoneal injection, 10 mg/kg, once every 2 days) inhibits subcutaneous ovarian cancer growth in A2780 and SKOV3 mouse subcutaneous xenograft models.
Storage & Handling
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
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