Product Name
SLC11A2 Polyclonal Antibody (RBITC)
Description
RBITC Conjugated Rabbit Polyclonal Antibody to SLC11A2.
Species/Host
Rabbit
Isotype
IgG
Clonality
Polyclonal
Conjugation
RBITC
Immunogen
KLH conjugated synthetic peptide derived from human SLC11A2 AA 251-350/568.
Reactivity
Human, Mouse, Rat, Chicken
Purity
Purified by Protein A.
Applications
WB, FCM, IF(IHC-P), IF(IHC-F), IF(ICC)
Dilution Range
WB: 1/300-5000, FCM: 1/20-100, IF(IHC-P): 1/50-200, IF(IHC-F): 1/50-200, IF(ICC): 1/50-200
Concentration
1 µg/ul
Note
For research use only
Target
DMT1
Gene Name
solute carrier family 11 member 2
Gene Abbr.
SLC11A2
Gene ID
UniProt ID
Molecular Weight
62 kDa
Alternative Names
DCT1, DMT1, NRAMP2, Natural resistance-associated macrophage protein 2, NRAMP 2, Divalent cation transporter 1, Divalent metal transporter 1, DMT-1, Solute carrier family 11 member 2, SLC11A2, OK/SW-cl.20
Cellular Localization
Cytoplasm.
Function
Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe2+ and TF-associated endosomal Fe2+ transport in erythroid precursors and other cells (By similarity).
Enables Fe2+ and Mn2+ ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (PubMed:24448823) (By similarity).
Can mediate uncoupled fluxes of either protons or metal ions.
Disease Area
Anemia, hypochromic microcytic, with iron overload 1 (AHMIO1), a hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size. The disorder is due to an error of iron metabolism that results in high serum iron, massive hepatic iron deposition, and absence of sideroblasts and stainable bone marrow iron store. Despite adequate transferrin-iron complex, delivery of iron to the erythroid bone marrow is apparently insufficient for the demands of hemoglobin synthesis.
Sequence Similarities
Belongs to the NRAMP family.
Storage
Store at -20°C. Avoid freeze/thaw cycles.
Storage Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Shipping
Shipped at 4°C
Form/Appearance
Liquid