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Docebenone
Cat. No. IC23066
CAS. No. 80809-81-0
Key Features and Details
Category
Inhibitor&Activator
Purity
99.10%
Formula
C21H26O3
Product Details
Product Name
Docebenone
CAS No.
80809-81-0
Molecular Weight
326.43
Target
5-LO
Synonyms
AA 861
Formula
C21H26O3
Appearance
Solid
Purity
99.10%
SMILES
O=C1C(CCCCC#CCCCC#CCO)=C(C)C(C(C)=C1C)=O
Product Overview
Description
Docebenone is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
In Vitro Activity
Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production.
In Vivo Activity
Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5 M.
Storage & Handling
Storage
Powder, -20 °C, 3 years; 4 °C, 2 years
In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
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