Artefenomel

Cat. No. IC23167

CAS. No. 1029939-86-3

Key Features and Details

Category

Inhibitor&Activator

Purity

98.16%

Formula

C28H39NO5

Product Size

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Product Details

Product Name

Artefenomel

CAS No.

1029939-86-3

Molecular Weight

469.61

Synonyms

OZ439

Formula

C28H39NO5

Appearance

Solid

Purity

98.16%

SMILES

[H][C@@]1(C[C@H](C2)C3)C4([C@@]3([H])C[C@H]2C1)O[C@]5(OO4)CC[C@H](CC5)C6=CC=C(C=C6)OCCN7CCOCC7

Product Overview

Description

Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2.

In Vitro Activity

Artefenomel (OZ439) (10 μg/mL, 2 h) can alkylate Plasmodium falciparum proteins. Artefenomel (0.3-300 μM) reduces ACE2 expression in Vero cells in a dose-dependent manner and does not induce any cytotoxicity at concentrations up to 300 μM. Artefenomel (33-100 μM) can completely prevent the virus-induced CPE and inhibit SARS-CoV-2 in a dose-dependent manner with an IC50 of 2.9 µM. Artefenomel (0-10 µg/mL) affects red blood cells and induces anaemia, thereby inducing histological changes (cell death) and macroscopic abnormalities in the embryo from pregnant Crl:CD(SD)BR rats.

Storage & Handling

Storage

-20 °C, protect from light, stored under nitrogen In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light, stored under nitrogen)

Shipping

Room temperature in continental US; may vary elsewhere.

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