JKE-1716

Cat. No. IC23179

CAS. No. 2421118-05-8

Key Features and Details

Category

Inhibitor&Activator

Formula

C20H20Cl2N4O4

Product Size

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Product Details

Product Name

JKE-1716

CAS No.

2421118-05-8

Molecular Weight

451.30

Formula

C20H20Cl2N4O4

SMILES

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C/C([N+]([O-])=O)=N/O

Product Overview

Description

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition.

In Vitro Activity

JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability. JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4.

Storage & Handling

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

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