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Tubulin Inhibitor 30
Cat. No. IC23221
CAS. No.
Key Features and Details
Category
Inhibitor&Activator
Formula
C22H19N3O5
Product Details
Product Name
Tubulin Inhibitor 30
Molecular Weight
405.4
Target
Tubulin
Formula
C22H19N3O5
IC50/EC50
IC50: 0.52 μM
SMILES
COC1=CC(C(C2=CN(C=C2C3=CC=CO3)C4=NC=CC=N4)=O)=CC(OC)=C1OC
Product Overview
Description
Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis.
In Vitro Activity
Tubulin inhibitor 30 (Compound 15) (0-100 nM; 48 h) inhibits the viability of MCF-7, U-87 MG and OVCAR-3 cells.
Tubulin inhibitor 30 is metabolically stable when incubated with human liver microsomes.
In Vivo Activity
Tubulin inhibitor 30 (Compound 15) inhibits the in vivo tumorigenicity of the human GBM cell line U-87 MG and the human OC cell line SKOV-3, and causes oxidative stress injury and Fe2+ accumulation in mice.
Storage & Handling
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
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