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Alogliptin Benzoate
Cat. No. IC23063
CAS. No. 850649-62-6
Key Features and Details
Category
Inhibitor&Activator
Purity
99.96%
Formula
C25H27N5O4
Product Details
Product Name
Alogliptin Benzoate
CAS No.
850649-62-6
Molecular Weight
461.51
Target
DPP-4
Synonyms
SYR 322
Formula
C25H27N5O4
Appearance
Solid
Purity
99.96%
IC50/EC50
IC50: <10 nM
SMILES
O=C(C=C(N1C[C@H](N)CCC1)N(C2=O)CC3=C(C#N)C=CC=C3)N2C.O=C(O)C4=CC=CC=C4
Product Overview
Description
Alogliptin Benzoate (SYR-322) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin Benzoate can be used for the research of type 2 diabetes.
In Vitro Activity
Alogliptin (1 nM; 5-60 min) inhibits LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation in U937 cells.
Alogliptin (0.5-5 nM; 24 h) inhibits LPS-stimulated MMP-1 secretion and mRNA expression that is mediated by ERK pathway in U937 cells.
In Vivo Activity
Alogliptin (0.01-1 mg/kg; p.o.) produced dose-dependent improvements in glucose tolerance and increased plasma insulin levels in female Wistar fatty rats.
Alogliptin (40 mg/kg/day for 2 weeks; p.o.) reduces infarction area and improves brain vascular integrity in middle cerebral artery occlusion (MCAO) mice.
Storage & Handling
Storage
4 °C, sealed storage, away from moisture
In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)
Shipping
Room temperature in continental US; may vary elsewhere.
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