Simvastatin-d6

Cat. No. IC23190

CAS. No. 1002347-71-8

Key Features and Details

Category

Inhibitor&Activator

Formula

C25H32D6O5

Product Size

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Product Details

Product Name

Simvastatin-d6

CAS No.

1002347-71-8

Molecular Weight

424.60

Synonyms

MK 733-d6

Formula

C25H32D6O5

SMILES

CCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O[C@@H]1[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H](O3)C[C@H](CC3=O)O)=C[C@H](C)C1)=O

Product Overview

Description

Simvastatin-d6 (MK 733-d6) is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.

In Vitro Activity

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

Storage & Handling

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

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