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Atorvastatin Hemicalcium Salt
Cat. No. IC23138
CAS. No. 134523-03-8
Key Features and Details
Category
Inhibitor&Activator
Purity
99.93%
Formula
C33H34Ca0.5FN2O5
Product Details
Product Name
Atorvastatin Hemicalcium Salt
CAS No.
134523-03-8
Molecular Weight
577.67
Synonyms
CI-981; Atorvastatin hemicalcium
Formula
C33H34Ca0.5FN2O5
Appearance
Solid
Purity
99.93%
SMILES
FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+]
Product Overview
Description
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
In Vitro Activity
Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.
Storage & Handling
Storage
4 °C, sealed storage, away from moisture
In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)
Shipping
Room temperature in continental US; may vary elsewhere.
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