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BCP-T.A
Cat. No. IC23218
CAS. No. 2786829-70-5
Key Features and Details
Category
Inhibitor&Activator
Formula
C23H19Cl2N3OS
Product Details
Product Name
BCP-T.A
CAS No.
2786829-70-5
Molecular Weight
456.39
Target
GPX4
Formula
C23H19Cl2N3OS
SMILES
O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=CSC(C#C)=N4
Product Overview
Description
BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4.
In Vitro Activity
BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC50 values of 10 nM-367 nM.
BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA).
Storage & Handling
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
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