PD146176
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PD146176

Cat. No. IC23158
CAS. No. 4079-26-9

Key Features and Details

Category
Inhibitor&Activator

Purity
98.04%

Formula
C15H11NS

Product Size

Product Details

Product Name
PD146176
CAS No.
4079-26-9
Molecular Weight
237.32
Synonyms
NSC168807
Formula
C15H11NS
Appearance
Solid
Purity
98.04%
SMILES
C1(N2)=C(CSC3=CC=CC=C31)C4=C2C=CC=C4

Product Overview

Description
PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
In Vitro Activity
In intact IC21 cells transfected with human 15-LO, PD146176 inhibits 13-HODE production with an IC50 of 0.81 μM.
In Vivo Activity
PD146176 (80 mg/kg; Chowing; 12 weeks) reverses cognitive impairment, brain amyloidosis, and Tau pathology by stimulating autophagy in aged triple transgenic mice.

Storage & Handling

Storage
Powder, -20 °C, 3 years; 4 °C, 2 years In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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